POLYMERS　Vol.58　No.3

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COVER STORY Polymers that Function within a Cell

Cellular phenomena are maintained by interactions of various macromolecules, such as proteins, carbohydrates, and nucleotides, together with other small molecules and ions in the tiny space of a cell. Biofunctional polymers, which control cellular phenomena through interaction with intracellular molecules or generate functions at a specific site of a cell or in a particular environment of a cell, could not only contribute to the elucidation of cellular phenomena, but also lead to the development of new functional materials for biotechnology, medicine and their related fields. This special issue features current topics of researches about polymers that function within a cell and their possibilities in the future. （Editors: KONO, AKIYOSHI and KAWAKAMI）

Commentary

Trials for Spatio-temporal Control of Intracellular Nano-world

Toshihiro AKAIKE

113

Hot Topics in Polymer Science in Japan

116

Polymer Science and I: A Personal Account

Nothing Becomes Reality Unless it is Experienced

Sadahiro MASUO

120

COVER STORY: Highlight Reviews

Regulation of Cellular Function by Viral Vectors	Mahito NAKANISHI	121
Genetically Encoded Fluorescent and Bioluminescent Indicator for Cellular Signaling	Asami KAIHARA	125
Polymers to Regulate Cell Functions for Regenerative Medicine	Yoshihiro ITO, Takashi KITAJIMA and Hiroshi ABE	129
The Significance and Attempt to Establish the Intracellular Targeting on Gene Delivery System	Shinji KAKIMOTO and Takeshi NAGASAKI	133

Glossary for Highlight Reviews

137

COVER STORY: Topics and Products

Polyion Complex to Synchronize Gene Release with Cellular Recognition	Shoichiro ASAYAMA	138
RNA Delivery using Cell-Permeable RNA-Binding Protein	Takashi OHTSUKI	140
In Cell Nucleic Acid Sensing	Shinsuke SANDO	142
Smart PEGylated Nanogel Particles for Apoptosis Imaging	Motoi OISHI	144

Front-Line Polymer Science

Amphiphilic Polymers in Aqueous Solution

Akihito HASHIDZUME and Takahiro SATO

146

Messages: “Work and Life”

Return From Nightmare	Shigeki MITAKU	151
What I thought at JAPAN-USA Seminar on Polymer Synthesis	Kyoko NOZAKI	152

Messages from SPSJ

154

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