| POLYMERS Vol.62 No.2 |
| >> Chinese | >> English | >> Japanese | >> Korean |
特集
以生物高分子为基础的无机材料的创制 |
| 展望 |
| 利用生物模板的纳米材料制备及其应用 | 岩堀健治，山下一郎 |
| <Abstract> 无机纳米材料有多种传统的制备方法，现在还有许多科学家在进行更加简便的制备方法的尝试。本文介绍了利用蛋白质模板来制备精细纳米材料的生物模板法，还介绍了这些材料的特征及应用。 Keywords: Nanomaterial / Nanoparticle / Ferritin / Nano- Devise / Bio-Template |
| Top of the Page▲ |
| Biomimetic Materials Synthesis and Self-Assembly for Device Fabrications: What Have We Done and Where Do We Go with This Technology | Hiroshi MATSUI |
| <Abstract> Peptides
and proteins are advantageous to develop complex and hybrid 3D assemblies
and materials due to their robust assembling nature, templating capability,
and molecular recognition. This review covers how the field of peptide-based
material sciences/engineering started, and continues to discuss the evolution
of technology from 2D to more complex 3D assemblies. Unique features
include the large scale assembly of nanomaterials in precise location,
periodicity, and interparticle distance, difficult to accomplish by other
technologies. Applications of biomolecular assemblies can be expected
in the fields of electronics, photonics, solar cells, medical devices,
tissue engineering, and metamaterials. Keywords: Bionanotechnology / Peptides / Protiens / 3D Self-Assembly / Biomaterials / Biomimetics |
| Top of the Page▲ |
| 无机晶体的生物矿化合成：晶体生长中的分子控制 | 今井宏明，绪明佑哉 |
| <Abstract> 无机固体和有机高分子复合体生物矿物的形成过程（生物矿化）有许多生物高分子进行参与。本文介绍了生物矿物的基本结构，同时还介绍了模仿生物矿化的无机晶体结构形成中的分子控制技术。 Keywords: Biomineral / Molecular Control / Crystal Growth / Organic Template / Soluble Molecule / Self-Organization |
| Top of the Page▲ |
| 话题 |
| 纳米材料为靶心的抗体在纳米微粒接合中的应用 | 梅津光央，服部峰充，熊谷 泉 |
| <Abstract> Antibodies,
with their high affinity and specificity, are widely utilized in the
field of protein engineering, medicinal chemistry, and nanotechnology
applications, and our recent studies have demonstrated the recognition
and binding of antibodies to the surface of inorganic material. High
affinity material-binding antibody fragments are generated on the single
variable domain of the heavy chain of a heavy chain camel antibody (VHH)
by a combination of peptide-grafting and phage-display techniques and
they can be used for one-pot functionalization of nanoparticles as interface
molecules. Multivalent and bispecific antibodies which are constructed
on the material-binding VHH platform by means of fusion technology functionalized
inorganic nanoparticles in one pot, and these functionalized nanoparticles
can be used to obtain surface plasmon resonance scattering images of
cancer cells and to spontaneously link two different nanomaterials. Here, we propose the bispecific antibodies
as convenient interface molecules in nano-sized world. Keywords: Antibody / Nanoparticle / Evolution Technology / Interface Molecule / Assembly |
| Top of the Page▲ |
| 珪藻类壳形成机理在生物氧化硅制备技术中的应用及其可能性 | 松田祐介 |
| <Abstract> Biomineralization
of silicate is commonly observed in nature. Lessons from diatom silica
shell (frustle) formation have indicated that, as one of the observed
natures of a frustle-forming factor, Silaffin, silica forming peptides
are strongly cationic. Our recent study demonstrated that basic amino
acids, lysine and arginine, also mineralize silicate by themselves, although
required concentrations of these free amino acids were above 5 mM while
cationic peptides required for efficient silica formation were about
30 nM in the presence of 0.1 M silicate, indicating efficiency of more
than two orders of magnitude higher compared to free amino acids. Amphipathic
α-helix peptide was obtained from a diatom pyrenoid forming carbonic
anhydrase, PtCA1, and basic amino acids were introduced to this helix
by gene engineering. Resulting cationized-diatom-pyrenoid-forming factor,
CDPF, revealed biosilica formation with high activity which is equivalent to that of diatom Silaffin. Our study
demonstrates a high potential to create silica-based materials using
peptides which are obtained from natural resources or protein engineering. Keywords: Diatom / Biosilica / Cationic Peptide / Protamine |
| Top of the Page▲ |
| 肽脂质自发构筑的金属络和物型有机纳米管的制备 | 小木曾真树，青柳 将 |
| <Abstract> Organic
nanotubes (ONTs) are expected as a novel nano-container for versatile
functional materials. Peptide lipids comprising of a glycyl-glycine and
an alkyl chain self-assemble to form the organic nanotubes through unique
polyglycine-II type hydrogen-bond networks. Metal-complexed organic nanotubes
(M-ONTs) are unique ONTs made of metal-complex of the peptide lipids.
When an aqueous solution of metal salt was added to a dispersion of the
peptide lipids in alcohol, M-ONTs were produced immediately. We can obtain
more than 100 g of dry M-ONTs using 1 L of water-alcohol mixture in a
few hours. Metal ions exist both on the inner- and outer surfaces and
in-between bilayer membranes. These M-ONTs are expected as novel metal
or metal-organic hybrid nanomaterials through metallization using organic
layers as templates. Applications as a catalyst were also investigated.
Single bilayer Ni-ONT showed high catalytic activities toward the oxidation of a variety of organic molecules. Keywords: Metal Complex / Organic Nanotube / Peptide / Self-Assembly / Catalyst |
| Top of the Page▲ |
| 使用高分子模板的有机无机复合物的研究 | 西村达也 |
| <Abstract> Biominerals
such as bones, teeth, the nacre of seashells, and the exoskeletons of
crustaceans are organic/inorganic hybrids with highly controlled hierarchical
structures. We have been inspired by the structure, properties and formation
processes of biominerals for the development of new functional hybrid
materials. We previously reported on the formation of thin films of inorganic
crystals based on this approach. The resulting hybrid materials consisting
of inorganic crystals and organic polymers exhibited a wide variety of
morphologies. Here we discuss our recent results for the development
of new inorganic/organic hybrid materials. Unidirectionally oriented
thin films and macroscopically oriented crystals have been obtained by
using functional polymer templates. Keywords: Biomineralization / Polymer Templates / Organic / Inorganic Hybrids / Recombinant Peptides / Calcium Carbonate |
| Top of the Page▲ |
| 高分子科学与我：个人独白 |
| Growing from “DA-RA-BU-CHI” | 遠藤洋史 |
| <Abstract> Was myself able to really growing from DA-RA-BU-CHI, which means a foolish person in Toyama prefecture? As for the research life through all my fortunes will be continued. |
| Top of the Page▲ |
| 高分子科学最新进展 |
| 层层组装技术，何去何从？ | 有贺克彦 |
| <Abstract> 由于层层组装技术(LbL)在材料应用方面的通用性和简易性，近年来它在基础科学和应用研究两个方面都得到了迅速的发展。这种方法已被应用到包括石墨和介孔材料的各种纳米材料研究中。比如，石墨烯纳米膜和离子液体的LbL组件对具有规则性π电子结构的芳香族化合物显示出良好的传感亲和性。介孔二氧化硅胶囊被纳入的LbL结构延伸出一种无刺激自动传输释放的新型药物传输系统。最近的其他研究也显示出LbL薄膜在生物医学应用和集成器件结构方面的很高的潜力。基于这些特征，我非常期待LbL技术的光明未来。 Keywords: Layer-by-Layer (LbL) Assembly / Thin Film / Nanomaterials / Graphene / Mesoporous Silica / Biomedical Application / Device |
| Top of the Page▲ |
| Copyright(C) 2012 The Society of Polymer Science, Japan All Rights Reserved. |