高分子　Vol.58　No.12　2009年12月
高分子　Vol.58　No.12
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特集　肌と高分子
グローイングポリマー　Polymer Science and I: A Personal Account
さまざまな「きっかけ」に支えられた研究人生
My Research Life Supported by Various “Motivators”		 金子　芳郎
Yoshiro KANEKO
＜要旨＞My research life has been supported by various ﾒmotivatorsﾓ such as the encounters with wonderful people and the discovery of interesting materials.
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ものづくりの魅力
Attraction of Product Development		 渡邉　真里子
Mariko WATANABE
＜要旨＞In this essay, I will write down some experience how I got attracted to and impressed by some fields and problems in my academic and industrial research life.
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展望　COVER STORY: Highlight Reviews
人工皮膚
Artificial Skin		 黒柳　能光
Yoshimitsu KUROYANAGI
＜要旨＞人工皮膚は，創傷被覆材と培養皮膚代替物に大別される。前者は，合成高分子材料で創傷面を物理的に被覆することにより外部からの細菌の侵入を阻止し，創傷面を湿潤環境に保って治癒を促進するものである。後者は，生体内分解性高分子材料と皮膚由来の細胞を利用し，細胞から産生される細胞成長因子の生物学的作用により治癒を促進するものである。
Keywords: Biomaterial / Cell / Growth Factor / Wound Dressing / Cultured Skin Substitute / Wound Healing
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皮膚組織再生のための高分子多孔質材料
Polymer Porous Scaffolds for Skin Tissue Engineering		 陳　国平
Guoping CHEN
＜要旨＞生体吸収性高分子からなる多孔質材料は，皮膚の創傷を治療するために，表皮や真皮，表皮・真皮複合皮膚組織の再生に利用されている。その一部は，医療用としてすでに承認され，臨床で使用されているが，まだ研究開発の段階のものも多い。本稿では，皮膚組織再生用の高分子多孔質材料の現状と今後の展開について述べる。
Keywords: Biodegradable Polymer / Porous Scaffold / Tissue Engineering / Skin / Dermal / Epidermal
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褥瘡の予防　圧迫と摩擦・ずれの管理
Pressure Ulcer Prevention: Managing Tissue Loads		 須釜　淳子
Junko SUGAMA
＜要旨＞褥瘡とは，身体に加わった外力が骨と皮膚表層の間の軟部組織の血流を低下，あるいは停止し，この状況が一定時間持続されると組織が不可逆的な阻血性障害に陥る病態である（2005，日本褥瘡学会）。原因である外力を減少させるために高分子個体の粘弾性などの性質を活用した製品が開発され，褥瘡発生予防効果をあげている。
Keywords: Pressure Ulcer / Support Surface / Pressure Redistribution / Polyurethane Foam
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フタロシアニン染色繊維のアレルゲン分子への効果
The Effect of Phthalocyanine-Dyed Fiber on Allergen Molecules		 矢野　裕之・草田　修・黒田　秧
Hiroyuki YANO, Osamu KUSADA, and Shigeru KURODA
＜要旨＞痒みをともなうアレルギー性疾患は近年増加傾向にある。フタロシアニンで染色した繊維は，ハウスダスト，食品および花粉の主要なアレルゲンを多量に吸着することによりアレルギー症状を軽減し，また低濃度の陰イオン界面活性剤（すなわち洗濯などの条件）で容易に解離し，吸着能が繰り返し再生される。こうしたフタロシアニン染色繊維のアレルゲン分子の吸着特性を，痒み軽減効果と関連づけて紹介する。
Keywords: Allergy / Itchiness / Phthalocyanine
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トピックス　COVER STORY: Topics and Products
高吸湿性アクリレート系繊維
Modified Acrylic Fiber with High Moisture Absorption		 石丸　園子
Sonoko ISHIMARU
＜要旨＞The modified acrylic fiber has a high moisture absorption capacity.
Since the heat value from absorption is very high, wearing clothes made from the fiber brings us warmth in very cold ambient temperature. On the other hand, it makes us feel not so hot or sweaty, even when the weather is very humid.
Keywords: Modified Acrylic Fiber / Hydrophilic Fiber / Heat of Absorption / Thermal Comfort
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生体適合性ポリマー
Biocompatible Polymer		 島田　邦男
Kunio SHIMADA
＜要旨＞The 2-Methacryloyloxyethylphosphoryl Choline (MPC) polymer is perfectly suitable for artificial organs due to its property to form a human cell membrane like surface structure. The effectiveness of the MPC polymer as a cosmetic additive is evaluated, and it shows an excellent damage prevention effect for skin.
Keywords: MPC Polymer / Artificial Organs / Human Cell Membrane / Cosmetic Additives / Damage Prevention Effect
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アスタキサンチンナノ乳化物の開発
Development of Astaxanthin Nano Emulsion		 田代　朋子
Tomoko TASHIRO
＜要旨＞Astaxanthin, a natural carotenoid, is well known as a strong singlet oxygen scavenger. In order to avoid the promotion of its oxidation in the nano emulsion, a combination of stabilizers has been extensively investigated and optimized. Moreover, coalescence of nano emulsion droplets has been successfully inhibited by the proper choice of emulsifiers.
Keywords: Astaxanthin / Anti-Oxidant / Nano Emulsion
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ジェミニ型両親媒性化合物の機能と生体への作用
Function of a Novel Gemini-Type Peptide Amphiphile and its Application to Skin Damage		 山本　政嗣・山脇　幸男・田村　幸永
Masashi YAMAMOTO, Yukio YAMAWAKI, and Yoshinaga TAMURA
＜要旨＞Gemini amphiphiles have become the subject of intense research in many laboratories. In our study, we developed a new type of Gemini amphiphile, sodium dilauramidoglutamide lysine (DLGL) consisting of two lauroylglutamates linked by lysine as a spacer. Here we report in particular its repair effects on damaged skin and other specific characteristics.
Keywords: Gemini Amphiphile / Penetration / Liquid Crystal / Gelation / Surface Active
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インジェクタブルゲルによる生体組織の接着
Injectable Gels for Bonding Soft Tissues		 田口　哲志
Tetsushi TAGUCHI
＜要旨＞Injectable gels have great potential to develop minimal invasive therapy. In this topic, we will introduce our recent results on two kinds of novel injectable gels which can bond the interface between soft tissues or cells.
Keywords: Injectable Gel / Organic Acid / Amphiphilic Polymer
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高分子科学最近の進歩　Front-Line Polymer Science
光・電子線硬化
UV/EB Curing		 鷲尾　方一・有光　晃二
Masakazu WASHIO and Koji ARIMITSU
＜要旨＞UV-Light/electron beam (UV/EB) processing technology utilizing chemical reactions induced by UV-light and EB irradiation has been widely used in a variety of industries. UV-Curing technology, which can be classified into three categories; UV-radical curing, UV-cation curing, and UV-anion curing, has mainly focused on surface finishing processes of various substrates such as plastics and metal using polymerization of monomers and oligomers. On the other hand, EB technology has dealt with cross-linking reactions as well as polymerization process to create novel functional materials. Both technologies have advantages in energy utilizing efficiency and green chemistry when compared to thermal processing and also have a high potential to grow in importance in the future. We describe here recent progress in UV-curing technology to improve mainly the inhibition of polymerization and in EB-curing technology advances concerning the practical application.
Keywords: UV / EB Curing / UV-Light / Electron Beam / Polymerization / Cross-Linking / Surface Finishing
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